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Search: WFRF:(Hardy J) > Hardy J. > Jönköping University

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1.	Jansen, I. E., et al. (author) Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk 2019 In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 404-413 Journal article (peer-reviewed)abstract Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (rg = 0.81). Meta-analysis identified 29 risk loci, implicating 215 potential causative genes. Associated genes are strongly expressed in immune-related tissues and cell types (spleen, liver, and microglia). Gene-set analyses indicate biological mechanisms involved in lipid-related processes and degradation of amyloid precursor proteins. We show strong genetic correlations with multiple health-related outcomes, and Mendelian randomization results suggest a protective effect of cognitive ability on AD risk. These results are a step forward in identifying the genetic factors that contribute to AD risk and add novel insights into the neurobiology of AD.
2.	Karlsson, Ida K., et al. (author) HERITABILITY OF ALZHEIMER'S DISEASE - COMPARISON OF TWIN AND POLYGENIC METHODS 2019 In: EUROPEAN NEUROPSYCHOPHARMACOLOGY. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 29, s. 1208-1209 Conference paper (other academic/artistic)

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Type of publication: journal article (1); conference paper (1)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Hardy, J (2)Undo refine; Karlsson, Ida K. (2); Steinberg, S (1); Aarsland, D (1); Wang, Y. (1); Watanabe, K. (1); show more...; Fladby, T (1); Rongve, A (1); Athanasiu, L (1); Djurovic, S (1); Sealock, J (1); Pedersen, NL (1); Hjerling-Leffler, J (1); Ripke, S (1); White, L.R. (1); Stefansson, K (1); Pedersen, N. L. (1); Gatz, M (1); Reynolds, CA (1); Andersen, F (1); Hägg, S (1); Bettella, F (1); Andreassen, O. A. (1); Stefansson, H. (1); Hohman, T. J. (1); Bryois, J (1); Escott-Price, V (1); Posthuma, D (1); Bråthen, G (1); Saltvedt, I (1); Selbæk, G (1); Stordal, E (1); van der Flier, W M (1); Sullivan, P. F. (1); Proitsi, P (1); Davis, L. K. (1); Dobson, R. (1); Williams, D M (1); Skene, N. G. (1); Bergh, S (1); Braekhus, A (1); Jansen, I. E. (1); Witoelar, A (1); Snaedal, J (1); Dumitrescu, L. (1); Sando, S. B. (1); Bjornsson, S (1); de Leeuw, C (1); Kiddle, S. J. (1); Stringer, S (1); show less...

University: Jönköping University (2)Undo refine; Karolinska Institutet (2)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2019 (2)

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